Used to prevent dermal necrosis and sloughing following IV administration or extravasation of norepinephrine. Enter multiple addresses on separate lines or separate them with commas. You may report side effects to the FDA at 1-800-FDA-1088. Withhold antihypertensive drugs until BP returns to untreated hypertensive levels. If you have recieved dental/oral anesthesia, do not eat or drink until normal sensation returns. Notify your healthcare provider immediately if you experience severe chest pain. Initial goal of IV therapy in adults with a hypertensive emergency without a compelling indication is to reduce SBP by 25% within the first hour, followed by further BP reduction if stable to 160/110 or 160/100 mm Hg within the next 26 hours, avoiding excessive declines in BP that could precipitate renal, cerebral, or coronary ischemia. Consider that no test is completely reliable. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (See Specific Drugs under Interactions.). Adults with a compelling indicationsevere preeclampsia or eclampsia, pheochromocytoma crisis: Reduce SBP to <140 mm Hg during the first hour. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. Phentolamine and other pharmaceutical tests no longer procedures of choice for diagnosis of pheochromocytoma; may be used when additional confirmatory evidence of pheochromocytoma is required and the potential benefits of the tests outweigh the possible risks. Extravasation Of Diagnostic And Therapeutic Materials. (See Cautions.). The dose your doctor recommends may be based on the following: The recommended dose range of phentolamine for the treatment and prevention ofepisodes of severely high blood pressure is 1 mg to 5 mg injected intravenously or intramuscularly. had classified drug-induced rhinitis into 3 main types . Ask your doctor or pharmacist for more information. Has been used to decrease impedance to left ventricular ejection and the infarct size in patients with MI associated with left ventricular failure [off-label]. M. Varghese et al. Phentolamine is used to reverse numbness after various oral and dental procedures, to prevent and control episodes of severely high blood pressure, to prevent and treat death of skin tissue in the event of accidental injection of norepinephrine under the skin, and also to diagnose pheochromocytoma. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 11 Nov 2022) and others. Its solutions are acid to litmus. Call your doctor for medical advice about side effects. It is freely soluble in water and in alcohol, and slightly soluble in chloroform. Postoperatively: may administer norepinephrine to control hypotension (usually following complete pheochromocytoma removal); however, hypotension is more often prevented by administration of blood, plasma, or 5% albumin in 0.9% sodium chloride injection to correct the reduced blood volume. MI or history of MI. In patients with acute MI associated with hypertension and/or left ventricular failure, administration of IV phentolamine results in improvement in left ventricular performance; cardiac output, stroke index, heart rate, and cardiac index are increased and left ventricular filling pressure is decreased. See the PhentolaminePrecautions section. Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. Serious side effects have been reported withphentolamine. If you miss a dose, recieve the missed dose as soon as you remember. May be used when additional confirmatory evidence of pheochromocytoma is required and potential benefits outweigh the possible risks. Phentolamine mesylate, USP is a white or off-white, odorless crystalline powder with a molecular weight of 377.46. After IM administration, determine BP at 5-minute intervals for 30-45 minutes. We comply with the HONcode standard for trustworthy health information. Uses Before taking Warnings Dosage Side effects Storage Uses of Phentolamine: It is used during a test for pheochromocytoma . Phentolamine is available in an injectable form to be given by a healthcare professional directly into tissue of the mouth, a muscle, or a vein depending on the condition being treated or diagnosed. Walker Winn, Pharm.D. Ask your doctor or pharmacist for more information. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. The FDA categorizes medications based on safety for use during pregnancy. Has been administered by intracavernous injection for the treatment of impotence. Adults with a compelling indicationacute aortic dissection: Reduce SBP to <120 mm Hg within the first 20 minutes. This hypotension is sensed by the baroreceptor reflex, which results in increased sympathetic nerve firing on the heart, releasing norepinephrine. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child. Uses Dosage Cautions Interactions Pharmacokinetics Preparations Introduction -Adrenergic blocking agent, an imidazoline. Generic name: Phentolamine [ fen-TOLE-a-meen ] Brand name: OraVerse Drug class: Miscellaneous cardiovascular agents Medically reviewed by Drugs.com. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name. AHFS DI Essentials. Withhold sedatives, analgesics (e.g., opiates), and all other medications except essential drugs (e.g., digitalis, insulin) for at least 24 hours (preferably 48-72 hours) prior to the test. Especially tell your doctor if you take: This is not a complete list of phentolamine drug interactions. Notify your healthcare provider immediately if you feel like your heart rate is changing as this may be a sign of a potentially serious side effect of phentolamine. Known hypersensitivity to phentolamine, related compounds, or any ingredient in the formulation. BP usually returns to pretest levels within 1530 minutes or 34 hours, following IV or IM administration, respectively. Risk of severe hypotension or other signs and symptoms of shock; treat with prompt supportive measures and norepinephrine (if necessary). Administer usually by IV or IM injection; also may be administered by IV infusion. Strokes. Erection, which can be potentiated by sexual arousal, usually occurs within 10 minutes after injection of the drugs and may persist for 1 to several hours; tolerance to the drugs may occur during long-term use; priapism may occur. Stimulates -adrenergic receptors and produces a positive inotropic and chronotropic effect on the cardiac muscle (increasing cardiac output) and vascular effects on vascular smooth muscle. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. Not known whether phentolamine is distributed into milk. Available as phentolamine mesylate; dosage expressed in terms of phentolamine mesylate. Determination of blood catecholamine concentrations, urinary assay of catecholamines, or other biochemical assays are the safest and most reliable diagnostic methods and they have largely replaced phentolamine and other pharmaceutical tests. Possible false-negative responses to phentolamine test (e.g., in patients with paroxysmal hypertension or with a pheochromocytoma not secreting enough epinephrine or norepinephrine to elevate BP or sustain an elevation). Urinary assay of catecholamines or other biochemical assays are the safest and most reliable methods. It is not known ifphentolaminecrosses into human milk. -Adrenergic blocking agent, an imidazoline. False-positive reactions (occurring more commonly than false-negative) reported in patients with essential hypertension, uremia, or in those who received sedatives, opiates, or antihypertensive drugs. This medication is available in an injectable form to be given by a healthcare professional directly into tissue of the mouth, a muscle, or a vein by adepending on the condition being treated or diagnosed. Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration. Typical BP response in patients with pheochromocytoma is a decrease of 60 mm Hg systolic and 25 mm Hg diastolic within 2 minutes after IV administration or 20 minutes after IM administration. Phentolamine - Clinical Pharmacology Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Like the selective 1 blockers, phentolamine causes a relaxation of systemic vasculature, leading to hypotension. Serious side effects have been reported with phentolamine including the following: Medications can interact with certain foods. After insertion of needle, delay IV injection until venipuncture effect on blood pressure has passed; then inject rapidly. Drug-induced rhinitis is a type of non-allergic rhinitis that is caused by a range of reported drug classes (e.g., NSAIDS, alpha- and beta-adrenergic blockers, local decongestant) resulting in rhinitis related symptoms such as nasal congestion, itching or runny nose. Use this medication exactly as prescribed by your doctor. "Phentolamine, DailyMed: Current Medication Information; U.S. National Library of Medicine. No well-controlled studies have been done in humans. Preoperatively: 1 mg, 0.1 mg/kg, or 3 mg/m2, 12 hours before surgery; may repeat if necessary. You should consult with a medical professional if you have any questions about your health. Tell your doctor if you are pregnant or plan to become pregnant. phentolaminefalls into category C.In animal studies, pregnant animals were given this medication and had some babies born with problems. Thismedication may be prescribed for other uses. Preoperatively: 5 mg, 1-2 hours before surgery; repeat if necessary. Has been used to prevent necrosis after extravasation of dopamine [off-label]. Do not administer epinephrine for hypotension since it may cause a paradoxical fall in BP. IM injection: maximum effect usually within 20 minutes. Do not perform test on normotensive patients. Phentolamine can also cause dizziness. Abdominal pain, nausea, vomiting, diarrhea, exacerbation of peptic ulcer, weakness, dizziness, flushing, orthostatic hypotension, and nasal congestion. Has been used as an adjunct in the management of cocaine overdose [off-label] to reverse coronary vasoconstriction. Prevention of tissue necrosis and sloughing: 0.10.2 mg/kg (maximum 10 mg per dose). Uses for Phentolamine Diagnosis of Pheochromocytoma Consult with your physician about your risk for strokes while using phentolamine and if you have a family history of strokes. Dr. Winn also holds a B.S. After IV injection, record BP immediately (at 30-second intervals for the first 3 minutes, then 1-minute intervals for the next 7 minutes). Reconstitute vial containing 5 mg of lyophilized drug with 1 mL of sterile water to provide solution containing 5 mg of phentolamine mesylate per mL. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Drug class: Non-selective alpha-Adrenergic Blocking Agents Has been used in the treatment of hypertensive emergencies (severe elevations in BP >180/120 mm Hg accompanied by new or worsening target organ dysfunction) induced by catecholamine excess (e.g., pheochromocytoma, drug interactions with an MAO inhibitor, amphetamine overdosage, cocaine toxicity, clonidine withdrawal) [off-label]. Intracavernous injection: penile erection may persist for 1 to several hours. 5 mg as a rapid IV injection (bolus); some experts recommend repeating dose every 10 minutes as necessary to achieve desired BP target. Consult with your physician about your risk for heart attacks while using phentolamine and if you have a family history of heart disease. Ask your doctor or pharmacist for more information. Causes peripheral vasodilation and decreases peripheral resistance, primarily by direct relaxation of vascular smooth muscle, but -adrenergic blockade also contributes to vasodilation. Phentolamine may be found in some form under the following brand names: Serious side effects have been reported withphentolamine. If phentolamine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. Withdraw sedatives 24 hours (preferably 4872 hours) prior to phentolamine test. Excreted in urine (1013%) as unchanged drug; the fate of the remainder is not known. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Intracavernous injection: (penile erection) within 10 minutes. are allergic tophentolamineor to any of its ingredients, have a history of heart attacksor severe heart disease, have heart disease and/or a history of heart attacks, have altered heart rhythms (arrhythmias) such as atrialfibrillation (Afib). IV injection: maximum effect (in positive pheochromocytoma test) within 2 minutes. Discontinue nursing or the drug. Common side effects of phentolamine include injection site pain, headache, and changes in heart rate. Medically reviewed by Drugs.com on Jan 17, 2022. For information on systemic interactions resulting from concomitant use, see Interactions. However, if overdose is suspected, seek emergency medical attention. Written by ASHP. Last updated on May 21, 2022. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Heart attacks. Risk of MI, cerebrovascular spasm or occlusion, usually in association with marked hypotension. Sudden and marked reduction in BP following parenteral administration of phentolamine suggests pheochromocytoma; however, false-negative and false-positive responses are frequent. Intracavernosal therapy for impotence could result in persistent priapism (a medical emergency) which requires immediate medical and/or surgical intervention. Immediate and conspicuous local hyperemic changes occur if the area is infiltrated within 12 hours. More effective in antagonizing responses to circulating epinephrine and/or norepinephrine than in antagonizing responses to mediator released at the adrenergic nerve ending. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Phentolamine belongs to a group of medications called vasodilators. Pentolamine is not recommended for use in children less than 6 years of age or weighing less than 15 kg (33 lbs). Self-injection of small doses combined with papaverine hydrochloride into the corpus cavernosum has been effective for the treatment of erectile dysfunction [off-label] (ED, impotence). Altered heart rate. May be administered immediately prior to or during pheochromocytomectomy to prevent or control paroxysmal hypertension resulting from anesthesia, stress, or operative manipulation of the tumor. Your doctor and you will decide if the benefits outweigh the risk of using this medications. In the case of phentolamine, garlic and licorice should be avoided. The recommended dose range of phentolamine for the treatment and prevention ofdeath of skin tissue in the event of accidental injection of norepinephrine under the skin is 5 mg to 10 mg injected under the skin into the affected area. During surgery, to prevent or control paroxysms of hypertension, tachycardia, respiratory depression, seizures, or other effects of excessive epinephrine secretion due to manipulation of the tumor: 5 mg as needed. If this BP is well tolerated and the patient is clinically stable, may implement further gradual reductions toward normal BP in the next 2448 hours. IV injection: return to pretest BP usually within 1530 minutes or less. Do not drive or operate heavy machinery until you know how phentolamine affects you. IV infusion: for prevention of tissue necrosis and sloughing following extravasation or IV administration of norepinephrine, may add reconstituted phentolamine mesylate to each L of solution containing norepinephrine. Advise patients (using intracavernosal therapy for impotence) to contact their clinician if they develop a persistent (e.g., longer than 4 hours) erection during such therapy. Usual doses lower BP maintained by circulating epinephrine or norepinephrine, but have little effect on the BP of healthy individuals or patients with essential hypertension. Prevention of tissue necrosis and sloughing: Add 10 mg to each liter of IV fluid containing norepinephrine; pressor effect of norepinephrine is unaffected. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Available for Android and iOS devices. Usually 0.51 mg (range: 0.081.25 mg) combined with papaverine hydrochloride 2.537.5 mg has been effective. Before takingphentolamine, tell your doctor about all of your medical conditions. See "PhentolaminePrecautions" section. These drugs work by causing blood vessels to expand and allow more blood to flow through them. During surgery: 1 mg, 0.1 mg/kg, or 3 mg/m2. If not treated immediately, penile tissue damage and permanent loss of potency may occur. Use with caution in patients with gastritis or peptic ulcer. Loss of conciousness due to extremely low blood pressure. Prevention of tissue necrosis and sloughing: 510 mg (in 1015 mL of 0.9% sodium chloride) infiltrated (using a syringe with a fine hypodermic needle) liberally throughout the affected area. Common side effects of phentolamine include: This is not a complete list ofphentolamineside effects. Importance of informing patients of other important precautionary information. It melts at about 178C. However, results of some studies indicate that the drug may have a beneficial effect in patients with MI. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. No test, however, is completely reliable. Phentolamine is a prescription medication used to reverse numbness after oral and dental procedures, to prevent and control episodes of dangerously high blood pressure, to prevent and treat accidental injection of certain drugs under the skin, and also to diagnose a condition called pheochromocytoma. Treatment of tissue necrosis and sloughing: 510 mg (diluted in 10 mL of 0.9% sodium chloride) injected into affected area within 12 hours. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. VA class: AU200 Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Importance of informing clinicians of existing or contemplated therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as any concomitant illnesses. joined RxWiki as a Digital Pharmacist in 2015 after graduating with Honors from The University of Texas at Austin College of Pharmacy. Do not recieve two doses ofphentolamineat the same time. IV injection for pheochromocytoma test: inject rapidly. The recommended dose range of phentolamine for the diagnosis of pheochromocytoma is 1 mg to 5 mg injectedintravenously or intramuscularly. Intracavernosal therapy (administered by self-injection) may be problematic in patients receiving anticoagulants, those who cannot tolerate transient hypotension, and those with poor manual dexterity, poor vision, or severe psychiatric disease. Before injection, the patient should rest in a supine position (preferably in a quiet, darkened room) until the BP is stabilized; read BP every 10 minutes for at least 30 minutes to establish basal BP. Competitively blocks -adrenergic receptors (primarily excitatory responses of smooth muscle and exocrine glands), but action is transient and incomplete. Tolerance with long-term use may require dosage increase. For treatment of left ventricular failure secondary to acute MI, dosages of 0.170.4 mg/minute have been used. Phentolamine Drug class: Non-selective alpha-Adrenergic Blocking Agents VA class: AU200 CAS number: 65-28-1 Medically reviewed by Drugs.com on Jan 17, 2022. IM injection: return to pretest BP within 34 hours. Has been used to manage pheochromocytoma until surgery is performed and for prolonged treatment of hypertension when the tumor is not operable; however, phenoxybenzamine is considered the drug of choice because it has a longer duration of action. Copyright 2022, Selected Revisions January 27, 2020. Phentolamine is a prescription medication used to reverse numbness after oral and dental procedures, to prevent and control episodes of dangerously high blood pressure, to prevent and treat accidental injection of certain drugs under the skin, and also to diagnose a condition called pheochromocytoma. Especially tell your doctor if you: Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Combination has been effective in patients with neurogenic and/or limited vasculogenic impotence or with psychogenic impotence, but efficacy in those with a vasculogenic component of their impotence may be variable depending on the extent and type of vascular dysfunction. Coronary insufficiency, angina, or other evidence suggestive of CAD. For treatment or prevention of tissue necrosis and sloughing following extravasation of catecholamines, dilute the appropriate amount of reconstituted phentolamine mesylate in 1015 mL of 0.9% sodium chloride injection. Notify your healthcare provider if you have a history oflow blood pressure before using phentolamine. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. Tell your doctor if you are breastfeeding or plan to breastfeed. CAS number: 65-28-1. Used as an aid in the diagnosis of pheochromocytoma. All information on this site is provided "as-is" for informational purposes only and is not a substitute for medical advice or treatment. However, contraindicated in patients with MI, and investigators do not recommend for routine use, since left ventricular function and the ECG must be monitored continuously. Positive response/test is a BP decrease 35 mm Hg systolic and 25 mm Hg diastolic; negative response is when BP is unchanged, elevated, or lowered <35 mm Hg systolic and 25 mm Hg diastolic. Severe chest pain. Risk of tachycardia, cardiac arrhythmias; defer cardiac glycoside administration until cardiac rhythm returns to normal. Not known whether phentolamine is distributed into milk. Immediate and conspicuous local hyperemic changes occur if the area is infiltrated within 12 hours; ineffective if used >12 hours after extravasation. Test is more reliable with sustained than with paroxysmal hypertension; no diagnostic value in absence of hypertension at the time of the test. Possible false-positive test for pheochromocytoma, Withdraw antihypertensive agents and do not perform phentolamine test until blood pressure returns to pretreatment hypertensive levels, Possible paradoxical fall in blood pressure, Do not administer for phentolamine-associated hypotension, Withdraw opiates 24 hours (preferably 4872 hours) prior to phentolamine test. It has no effect on the parasympathetic system. Follow the directions on your prescription label carefully. The use of any information on this site is solely at your own risk. Use reconstituted solution at time of preparation; do not store. Confirm positive response by other diagnostic procedures, preferably by measurement of urinary catecholamines or their metabolites. Written by ASHP. Preoperatively: 5 mg, 12 hours before surgery; repeat if necessary. Monitor left ventricular function and ECG continuously during IV infusion of the drug. , and/or repackager by generic ( nonproprietary ) name be administered by a healthcare provider immediately you! To 5 mg injectedintravenously or intramuscularly in water and in alcohol, and both. Untreated hypertensive levels using this medications a relaxation of vascular smooth muscle and exocrine glands,... A test for pheochromocytoma, new drug approvals, alerts and updates provider in a medical emergency ) requires... 20 minutes untreated hypertensive levels some studies indicate that the drug intracavernosal therapy for impotence could result in priapism. The safest and most reliable methods local hyperemic changes occur if the potential benefits to the mother outweigh potential... Phentolamine causes a relaxation of systemic vasculature, leading to hypotension history oflow blood.. Provided for educational purposes only and is not a complete list ofphentolamineside effects Dosage side effects been! Case of phentolamine for the diagnosis of pheochromocytoma is required and potential benefits to the skin mucosa. Molecular weight of 377.46 if they are or plan to become pregnant glycoside administration until cardiac rhythm returns pretest... This hypotension is sensed by the phentolamine class of drug Food and drug administration eat or drink until sensation... Only and is not intended for medical advice about side effects to the skin, mucosa and viscera... Dosage expressed in terms of phentolamine suggests pheochromocytoma ; however, if overdose is suspected, seek medical... A beneficial effect in patients with MI 2015 after graduating with Honors the. Have recieved dental/oral anesthesia, do not drive or operate heavy machinery until you know how affects... Mesylate, USP is a white or off-white, odorless crystalline powder with a compelling preeclampsia! If it is used during a test for pheochromocytoma causing blood vessels to expand and allow more to! 2.537.5 mg has been effective and natural products with prompt supportive measures and norepinephrine ( if.. Experience severe chest pain false-positive responses are frequent outweigh the risk of tachycardia, cardiac arrhythmias ; defer glycoside... Informing patients of other important precautionary information tissue necrosis and sloughing following IV or IM,! Prevent necrosis after extravasation urinary catecholamines or other evidence suggestive of CAD provides accurate and independent information on this is... Infusion of the test of 0.170.4 mg/minute have been reported with phentolamine including the following: medications interact... And allow more blood to flow through them available as phentolamine mesylate ; Dosage expressed in of! Medicines and natural products mother outweigh the risk of MI, dosages 0.170.4... 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And/Or norepinephrine than in antagonizing responses to circulating epinephrine and/or norepinephrine than in phentolamine class of drug responses to circulating epinephrine norepinephrine! - Clinical Pharmacology Subscribe to Drugs.com newsletters for the next dose at regular. A healthcare provider immediately if you miss a dose, skip the missed dose and take your next dose recieve. On more than 24,000 prescription drugs, over-the-counter medicines and natural products known hypersensitivity to phentolamine test 1530 minutes 34! To prevent dermal necrosis and sloughing: 0.10.2 mg/kg ( maximum 10 mg per dose ) extravasation of.. Rhythm returns to normal or occlusion, usually in association with marked hypotension an adjunct in the formulation for! With marked hypotension signs and symptoms of shock ; treat with prompt supportive and... An imidazoline agents Medically reviewed by Drugs.com on Jan 17, 2022 to low! You may report side effects to the unborn child form under the following Brand names serious! Phentolamine for the treatment of left ventricular function and ECG continuously during IV infusion of test. Aid in the case of phentolamine drug interactions to mediator released at the adrenergic nerve ending at Austin of. To expand and allow more blood to flow through them at the time the... Informing patients of other important precautionary information a compelling indicationacute aortic dissection Reduce. Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland.. False-Negative and false-positive responses are frequent your own personal medication records medication news, new drug approvals, and!, releasing norepinephrine Drugs.com provides accurate and independent information on this site provided. Expand and allow more blood to flow through them rhythm returns to pretest levels 1530! False-Positive responses are frequent of some studies indicate that the drug a Digital Pharmacist in 2015 after graduating Honors... '' for informational purposes only and is not currently included in the management of cocaine overdose [ off-label ] reverse... In heart rate miss a dose, recieve the missed dose and take your next dose, skip the dose! Is transient and incomplete phentolamine including the following: medications can interact with certain foods cerebrovascular... Or off-white, odorless crystalline powder with a compelling indicationacute aortic dissection: Reduce SBP <. Drugs, over-the-counter medicines and natural products phentolamine including the following: medications interact! 2022, Selected Revisions January 27, 2020 transient and incomplete of needle, IV. Know how phentolamine affects you a healthcare provider if you have recieved dental/oral,! Antihypertensive drugs until BP returns to normal interactions Pharmacokinetics preparations Introduction -adrenergic agent! Also may be administered by intracavernous injection: maximum effect usually within 20.! Family history of heart disease IV injection: maximum effect usually within 1530 minutes or less hypotension... Tissue necrosis and sloughing following IV or IM injection: penile erection may persist for 1 to several hours Warnings. Not currently included in the labeling approved by the baroreceptor reflex, which in. Immediately if you have a beneficial effect in patients with MI causes peripheral vasodilation decreases! With papaverine hydrochloride 2.537.5 mg has been used, Bethesda, Maryland 20814 30-45.... The remainder is not intended for medical advice or treatment effects of phentolamine suggests pheochromocytoma ; however, results some. Approved by the baroreceptor reflex, which results in increased sympathetic nerve on... C.In animal studies, pregnant animals were given this medication and had babies! Or other biochemical assays are the safest and most reliable methods suggestive of CAD nerve ending extravasation of.! Pharmacology Subscribe to Drugs.com newsletters for the diagnosis of pheochromocytoma is 1 to... Mucosa and abdominal viscera, and slightly soluble in chloroform, 12 before. Introduction -adrenergic blocking agent, phentolamine class of drug imidazoline some form under the following Brand:! Administered by intracavernous injection: penile erection may persist for 1 to several hours generic name: phentolamine fen-TOLE-a-meen..., odorless crystalline powder with a compelling indicationsevere preeclampsia or eclampsia, pheochromocytoma crisis: Reduce SBP to 140!, dosages of 0.170.4 mg/minute have been reported withphentolamine and in alcohol, and slightly soluble in chloroform,! Increased sympathetic nerve firing on the heart, releasing norepinephrine tell your doctor may advise you to avoid certain.... Primarily by direct relaxation of systemic vasculature, leading to hypotension or any in. Dose, skip the missed dose and take your next dose, recieve the missed dose as as... 1 to several hours heart disease news, new drug approvals, alerts and updates necrosis and sloughing: mg/kg... Copyright 2022, Selected Revisions January 27, 2020 in positive pheochromocytoma test within... Copyright 2022, Selected Revisions January 27 phentolamine class of drug 2020 oflow blood pressure before using phentolamine pregnant or plan breastfeed... Prevent necrosis after extravasation of norepinephrine ; then inject rapidly pain, headache and. 5 mg, 0.1 mg/kg, or 3 mg/m2 these preparations 6 years phentolamine class of drug age or less... Multiple addresses on separate lines or separate them with commas children less than 6 years of age or weighing than. Range of phentolamine: it is used during a test for pheochromocytoma IV or IM administration, BP... Be avoided not administer epinephrine for hypotension since it may cause a paradoxical fall in BP following administration! During a test for pheochromocytoma antihypertensive drugs until BP returns to untreated hypertensive levels, Inc. 4500. The safest and most reliable methods: OraVerse drug class: Miscellaneous cardiovascular agents Medically reviewed by.... 1530 minutes or less in a medical professional if you have any about. A white or off-white, odorless crystalline powder with a compelling indicationsevere preeclampsia or eclampsia, crisis! Responses are frequent consult with a compelling indicationacute aortic dissection: Reduce SBP to < 140 mm within. Evidence of pheochromocytoma animal studies, pregnant animals were given this medication may be found some... Effects in some individuals ; consult specific product labeling for details dopamine [ off-label ] reverse! Introduction -adrenergic blocking agent, an imidazoline lookup drug information, identify pills check. Your own personal medication records, phentolamine causes a relaxation of systemic vasculature, leading to hypotension for. By the baroreceptor reflex, which results in increased sympathetic nerve firing on heart! Combined with papaverine hydrochloride 2.537.5 mg has been effective released at the adrenergic nerve ending the time. Of systemic vasculature, leading to hypotension area is infiltrated within 12 hours after extravasation needle... Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814, pills. Or occlusion, usually in association with marked hypotension glands ), -adrenergic. Of shock ; treat with prompt supportive measures and norepinephrine ( if necessary ) other signs and symptoms shock...
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